Autoimmune hemolytic anemia, abbreviated as AIHA, is a somewhat uncommon type of anemia, during which a person's body develops and produces antibodies that are targeted against its own red blood cells. This causes a unfortunate phenomenon where the premature and permanent destruction of these cells is accomplished over time. Liposomal clodronate is a substance that has recently caught the eye of many medical and health scientists, and it is currently being studied and tested as a potential treatment for AIHA.
In a vast number of cases, surgery must be performed to treat the aforementioned disorder. As most people are aware of, surgery of any type can result in complications. This is particularly true if the patient is of an advanced age or has additional health issues or underlying diseases.
Individuals who have poor immune systems are usually not appropriate candidates for surgical procedures. In addition, people who take specific drugs may have an increased risk for complications following surgery. This is why most of the clinical studies involving AIHA concentrate on finding new drugs with which to treat the disorder, instead of additional surgical options.
Thankfully, today's innovative technology has provided a way for researchers to isolate the kind of agent that is necessary to correct the destruction of red blood cells that occurs in individuals with AIHA. These are antimacrophage agents, which are vitally important if the red blood cell destruction is to be stopped in patients with this type of anemia.
Researchers have discovered that liposomally encapsulated clodronate can successfully counteract the imbalance that causes one to destroy his or her own blood cells. Further research was completed to find out if the initial discoveries were as promising in reality as they were in the preliminary studies.
To determine the effectiveness of this substance, a two-year study was completed on laboratory mice. Two groups of mice were given 2 distinctly different antibodies. In both groups, when liposomal clodronate was administered, it substantially lowered the speed at which the red blood cells were attacked. The benefits of the drug lasted as long as two weeks, and it took effect very quickly.
Health researchers and experts are optimistic concerning this drug and its potential benefits for AIHA patients. Many scientists are of the opinion that the use of this drug may offer the same health benefits as a medical procedure referred to as a medicinal splenectomy. Of course, the use of liposomally encapsulated clodronate would certainly be much less complicated than virtually any surgery. The substance may also be helpful in cases where a quick response to treatment is imperative.
In addition, positive results were observed when liposomal clodronate was used to suppress macrophage activity in various situations. These included organ transplants, autoimmune diseases, neurological disorders and gene therapy. For this reason, anyone suffering from AIHA has reason to hope that this drug may eventually be developed and marketed as a treatment or even a cure for this destructive blood disorder. However, additional research is still necessary to thoroughly understand all the beneficial effects of the drug.
In a vast number of cases, surgery must be performed to treat the aforementioned disorder. As most people are aware of, surgery of any type can result in complications. This is particularly true if the patient is of an advanced age or has additional health issues or underlying diseases.
Individuals who have poor immune systems are usually not appropriate candidates for surgical procedures. In addition, people who take specific drugs may have an increased risk for complications following surgery. This is why most of the clinical studies involving AIHA concentrate on finding new drugs with which to treat the disorder, instead of additional surgical options.
Thankfully, today's innovative technology has provided a way for researchers to isolate the kind of agent that is necessary to correct the destruction of red blood cells that occurs in individuals with AIHA. These are antimacrophage agents, which are vitally important if the red blood cell destruction is to be stopped in patients with this type of anemia.
Researchers have discovered that liposomally encapsulated clodronate can successfully counteract the imbalance that causes one to destroy his or her own blood cells. Further research was completed to find out if the initial discoveries were as promising in reality as they were in the preliminary studies.
To determine the effectiveness of this substance, a two-year study was completed on laboratory mice. Two groups of mice were given 2 distinctly different antibodies. In both groups, when liposomal clodronate was administered, it substantially lowered the speed at which the red blood cells were attacked. The benefits of the drug lasted as long as two weeks, and it took effect very quickly.
Health researchers and experts are optimistic concerning this drug and its potential benefits for AIHA patients. Many scientists are of the opinion that the use of this drug may offer the same health benefits as a medical procedure referred to as a medicinal splenectomy. Of course, the use of liposomally encapsulated clodronate would certainly be much less complicated than virtually any surgery. The substance may also be helpful in cases where a quick response to treatment is imperative.
In addition, positive results were observed when liposomal clodronate was used to suppress macrophage activity in various situations. These included organ transplants, autoimmune diseases, neurological disorders and gene therapy. For this reason, anyone suffering from AIHA has reason to hope that this drug may eventually be developed and marketed as a treatment or even a cure for this destructive blood disorder. However, additional research is still necessary to thoroughly understand all the beneficial effects of the drug.
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